Set in modern day, Insanity opens with the discovery of a dead body – a girl whose face has been sewn up into a disturbing grin. The girl is the latest victim of the serial killer known as the Cheshire Cat. Back at Radcliffe Lunatic Asylum, Professor Carter Pillar, a hookah-smoking philosophy professor turned serial killer himself (known as Pillar The Killer), has a plan to stop the Cheshire Cat and ropes fellow patient Alice Wonder, a nineteen-year-old girl with no memories who was institutionalized after killing a bus-load of her peers, into helping. And it just dissolves into madness from there.